Angeles Health has been working on stem cell application trials for strokes and heart failure for some time now and it looks like US organizations are following suit.
A new study in which patients had their hearts repaired with stem cells shows that regenerative therapies for heart attacks are becoming more widespread, and we are moving closer to them being commonly used to improve heart problems.
The therapies cut in half the extent of what would normally have been permanent scarring on the heart, and brought about the growth of new heart muscle.
However, it caused no major change in ejection fraction – a measure of the heart’s pumping ability.
The Caduceus trial looked at 25 patients who had the average age of 53 and had suffered a heart attack the month before the research was carried out. Seventeen of them had coronary artery infusions of between 12 and 25million stem cells. These were taken from healthy tissue in their own hearts. The other eight patients received standard medical care. After one year the proportion of the heart scarring in patients who had the stem cell application had gone down from 24 per cent to 12 per cent. No change was observed in the patients who underwent the usual treatment options.
Professor Eduardo Marbán, director of the Cedars–Sinai Heart Institute in Los Angeles, led the US based team and commented: “This discovery challenges the conventional wisdom that, once established, scar is permanent and that, once lost, healthy heart muscle cannot be restored.”
The study was published in the online Lancet medical journal.
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